Camk4 Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Camk4 |
| Official Name | calcium/calmodulin-dependent protein kinase IV [Source:RGD Symbol;Acc:2264] |
| Ensembl ID | ENSRNOG00000020478 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase IV |
| Synonyms | A430110E23Rik, Ca2+-CaM kinase IV, calcium/calmodulin-dependent protein kinase IV, caMK, Camk4,alpha, Camk4,α, CaMK-GR, CAM KINASE4, CaMK IV, CaMKIV/Gr, Ccdpk, D18Bwg0362e, RATCCDPK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Camk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- autoinhibitory protein domain
- regulatory domain
- Protein Kinases, catalytic domain
- importin beta binding domain
- calmodulin binding domain
- protein binding
- Protein kinase domain
- calmodulin regulated protein kinase
Pathways
Biological processes and signaling networks where the Camk4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- BMP signaling pathway
- Calcium Signaling
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- G-Protein Coupled Receptor Signaling
- Glioma Signaling
- HIF1α Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Opioid Signaling Pathway
- Role of NFAT in Cardiac Hypertrophy
- Synaptic Long Term Potentiation
- Systemic Lupus Erythematosus Signaling
- Thrombin Signaling
- TR/RXR Activation
- Xenobiotic Metabolism Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- anovulation
- arrhythmia
- colorectal cancer
- hypothyroidism
- ataxia
- Huntington disease
- tremor
- insulin-dependent diabetes mellitus
- allergic asthma
role in cell
- apoptosis
- autophagy in
- expression in
- phosphorylation in
- proliferation
- binding in
- activation in
- invasion by
- degradation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent-insoluble membrane fraction
- soluble fraction
- nuclear matrix fraction
- glutaminergic synapse
- fibrillar center
- Cytoplasm
- postsynaptic region
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nuclear matrix
- synapse
- chromatin
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Camk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- adaptive immune response
- protein autophosphorylation
- regulation of T cell differentiation in thymus
- protein phosphorylation
- long-term memory
- inflammatory response
- positive regulation of transcription, DNA-dependent
- positive regulation of myeloid dendritic cell cytokine production
- myeloid dendritic cell differentiation
- regulation of osteoclast differentiation
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- calmodulin-dependent protein kinase activity
- calcium-dependent protein serine/threonine kinase activity