Faf1 Gene Summary [Rat]
Predicted to enable several functions, including NF-kappaB binding activity; enzyme binding activity; and ubiquitin binding activity. Predicted to be involved in ERAD pathway; positive regulation of macromolecule metabolic process; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and regulation of cell adhesion. Predicted to be located in several cellular components, including nucleus; ooplasm; and perinuclear region of cytoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in endoplasmic reticulum and nucleus. Orthologous to human FAF1 (Fas associated factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Faf1 |
| Official Name | Fas associated factor 1 [Source:RGD Symbol;Acc:70987] |
| Ensembl ID | ENSRNOG00000008523 |
| Bio databases IDs | |
| Aliases | Fas associated factor 1 |
| Synonyms | CGI-03, Dffrx, FAF, Fam, Fas-associated factor 1, hFAF1, HFAF1s, LOC112268262, UBXD12, UBXN3A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Faf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- protein kinase binding
- death effector domain-interacting domain
- Fas death domain-binding domain
- NF-kappaB binding
- heat shock protein binding
- coiled-coil domain
- protein domain specific binding
- ubiquitin binding
- protein binding
- ubiquitin-like domain
- Vacuolar (H+)-ATPase G subunit
- Ubl1_cv_Nsp3_N-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Fas binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastasis
- headache
- alopecia
- androgenic alopecia
- plasma cell myeloma
- rheumatoid arthritis
- ischemic stroke
- ventricular extrasystole
- diabetes mellitus
role in cell
- migration
- degradation in
- apoptosis
- cell death
- differentiation
- expression in
- accumulation in
- binding in
- mistargeting
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear envelope
- synaptosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Faf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cytoplasmic sequestering of NF-kappaB
- apoptotic process
- positive regulation of apoptotic process
- regulation of protein catabolic process
- positive regulation of protein catabolic process
- positive regulation of DNA replication
- regulation of cell adhesion
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- perinuclear region of cytoplasm
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- cytosol
- endoplasmic reticulum
- CD95 death-inducing signaling complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- heat shock protein binding
- protein kinase binding
- protein domain specific binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- protein kinase regulator activity