Ca4 Gene Summary [Rat]
Enables carbonate dehydratase activity. Involved in response to steroid hormone and response to xenobiotic stimulus. Located in apical plasma membrane; sarcolemma; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA4 (carbonic anhydrase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ca4 |
| Official Name | carbonic anhydrase 4 [Source:RGD Symbol;Acc:2242] |
| Ensembl ID | ENSRNOG00000002916 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 4 |
| Synonyms | CAIV, CAR4, carbonic anhydrase 4, carbonic anhydrase isozyme IV, Carbonic anhydrase IV, RP17 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ca4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- topiramate
- benzthiazide
- ethoxyzolamide
- acetazolamide
- ALDH1A2
- methazolamide
- chlorothiazide
- chlorthalidone
- hydrochlorothiazide
- dichlorphenamide
disease
- glaucoma
- weight gain
- obesity
- overweight disorder
- chronic obstructive pulmonary disease
- retinitis pigmentosa
- migraines
- obstructive sleep apnea
- congestive heart failure
- subarachnoid aneurysmal hemorrhage
role in cell
- expression in
- apoptosis
- acidification in
- acidification
- beat
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoplasmic vesicle membrane
- cell surface
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- Golgi Apparatus
- secretory granule membrane
- ER-to-Golgi intermediate compartment
- plasma membrane extracellular face
- apical membrane
- trans Golgi network
- cytoplasmic droplets
- sarcolemma
- rough endoplasmatic reticulum
- brush border
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ca4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bicarbonate transport
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- rough endoplasmic reticulum
- Golgi apparatus
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- cell surface
- secretory granule membrane
- trans-Golgi network
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- brush border membrane
- transport vesicle membrane
- membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- carbonate dehydratase activity