Pnlip Gene Summary [Rat]
Enables triacylglycerol lipase activity. Involved in post-embryonic development; response to lipid; and response to peptide hormone. Located in extracellular space. Used to study obesity. Orthologous to human PNLIP (pancreatic lipase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnlip |
| Official Name | pancreatic lipase [Source:RGD Symbol;Acc:3360] |
| Ensembl ID | ENSRNOG00000017725 |
| Bio databases IDs | |
| Aliases | pancreatic lipase |
| Synonyms | 1810007A24RIK, LOC108349706, Pancreatic lipase, PANLI, PL, PNLIPD, PTL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnlip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- colipase binding domain
- alpha/beta hydrolases
- lipase
- PLAT
- enzyme
- retinyl-palmitate esterase
- loop domain
- lipoprotein lipase
- lid domain
- Lipoxygenase homology 2 (beta barrel) domain
- triacylglycerol lipase
Pathways
Biological processes and signaling networks where the Pnlip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- overweight disorder
- binge eating disorder
- non-insulin-dependent diabetes mellitus
- obesity
- aldosterone producing adrenocortical adenoma
- adenoma formation
- nonalcoholic fatty liver disease
- heart disease
- hepatitis
regulates
- lipid
- triacylglycerol
- cholesterol
- digalactosyldiacylglycerol
- triolein
- retinyl palmitate
- tributyrin
- phosphatidylcholine
- tricaprilin
- retinyl ester
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pnlip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of triglyceride lipase activity
- lipid catabolic process
- lipid metabolic process
- retinol metabolic process
- intestinal cholesterol absorption
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
- triglyceride lipase activity
- lipase activity