Vegfb Gene Summary [Rat]
Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 1 binding activity. Involved in angiogenesis and response to xenobiotic stimulus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of retinal vein occlusion. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vegfb |
| Official Name | vascular endothelial growth factor B [Source:RGD Symbol;Acc:619799] |
| Ensembl ID | ENSRNOG00000021156 |
| Bio databases IDs | |
| Aliases | vascular endothelial growth factor B |
| Synonyms | vascular endothelial growth factor B, VEGFL, VRF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vegfb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PDGF
- chemoattractant
- protein binding
- vascular endothelial growth factor receptor binding
- identical protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Vegfb gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Bladder Cancer Signaling
- Clathrin-mediated Endocytosis Signaling
- Colorectal Cancer Metastasis Signaling
- Endocannabinoid Cancer Inhibition Pathway
- eNOS Signaling
- Estrogen Receptor Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17 Signaling
- IL-8 Signaling
- ILK Signaling
- mTOR Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- TR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- choroidal neovascularization
- neoplasia
- epithelial cancer
- advanced colon cancer
- metastatic colon cancer
- NRAS codon 12 mutation positive colorectal cancer
- retinopathy of prematurity
- metastatic rectal cancer
- colorectal cancer
- microsatellite instability high colon cancer
role in cell
- growth
- proliferation
- apoptosis
- expression in
- quantity
- activation in
- survival
- formation in
- phosphorylation in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- alpha granules
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vegfb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- positive chemotaxis
- sprouting angiogenesis
- vascular endothelial growth factor signaling pathway
- coronary vasculature development
- cardiac muscle contraction
- positive regulation of angiogenesis
- positive regulation of mast cell chemotaxis
- vascular endothelial growth factor receptor signaling pathway
- response to hypoxia
- positive regulation of cell division
- positive regulation of protein phosphorylation
- positive regulation of endothelial cell proliferation
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- growth factor activity
- protein binding
- vascular endothelial growth factor receptor binding
- chemoattractant activity
- heparin binding