Guk1 Gene Summary [Rat]
Enables guanylate kinase activity. Involved in glycoprotein transport; nucleoside phosphate metabolic process; and phosphorylation. Predicted to be located in mitochondrion and photoreceptor inner segment. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome-21. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Guk1 |
| Official Name | guanylate kinase 1 [Source:RGD Symbol;Acc:1309638] |
| Ensembl ID | ENSRNOG00000002928 |
| Bio databases IDs | |
| Aliases | guanylate kinase 1 |
| Synonyms | GMK, guanylate kinase 1, MTDPS21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Guk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- guanylate kinase
- dephospho-CoA kinase
- nucleoside-phosphate kinase
- NK
- ATP binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- glycoprotein
- purine nucleotide
- GUK1
- nitrogenous base
- nucleotide
- nucleoside
- xenobiotic
- GDP
- GMP
- dGMP
disease
- breast cancer
- preeclampsia
- mitochondrial DNA depletion syndrome
- renal cell carcinoma
- renal cell cancer
role in cell
- proliferation
- phosphorylation in
- survival
- clonogenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Guk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dGMP metabolic process
- purine nucleotide metabolic process
- dGDP biosynthetic process
- xenobiotic metabolic process
- nucleobase-containing small molecule interconversion
- GDP-mannose metabolic process
- GDP biosynthetic process
- GMP metabolic process
- phosphorylation
- dATP metabolic process
- glycoprotein transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- guanylate kinase activity