Fahd1 Gene Summary [Rat]
Predicted to enable hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; oxaloacetate decarboxylase activity; and oxaloacetate tautomerase activity. Predicted to be involved in oxaloacetate metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human FAHD1 (fumarylacetoacetate hydrolase domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fahd1 |
| Official Name | fumarylacetoacetate hydrolase domain containing 1 [Source:RGD Symbol;Acc:1304560] |
| Ensembl ID | ENSRNOG00000014727 |
| Bio databases IDs | |
| Aliases | fumarylacetoacetate hydrolase domain containing 1 |
| Synonyms | 1110025H10Rik, ApH, C16ORF36, fumarylacetoacetate hydrolase domain containing 1, ODx, RGD1304560, YISKL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fahd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit
- oxaloacetate decarboxylase
- ketonic substance carbon-carbon hydrolase
- Protein of unknown function (DUF2848)
- enzyme
- protein binding
- HpaG-C-term
- acetylpyruvate hydrolase
- oxaloacetate tautomerase
- Fumarylacetoacetate (FAA) hydrolase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
- premature ovarian failure type 23
- spermatogenic failure 22
regulated by
- tetradecanoylphorbol acetate
- GSKJ4
- magnesium
- genomic DNA
- SMYD1
- acetylpyruvic acid
regulates
- pyruvic acid
- succinate dehydrogenase
- acetylpyruvic acid
- GLS
- oxalacetic acid
- 3-fumarylpyruvate
role in cell
- cell death
- expression in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fahd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- oxaloacetate decarboxylase activity
- metal ion binding
- fumarylpyruvate hydrolase activity
- acylpyruvate hydrolase activity
- acetylpyruvate hydrolase activity