Ppl Gene Summary [Rat]
Predicted to enable structural molecule activity. Predicted to be involved in intermediate filament cytoskeleton organization; response to mechanical stimulus; and wound healing. Predicted to act upstream of or within regulation of antibacterial peptide production. Predicted to be located in plasma membrane. Predicted to be active in cornified envelope and cytoplasm. Predicted to colocalize with intermediate filament. Orthologous to human PPL (periplakin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppl |
| Official Name | periplakin [Source:RGD Symbol;Acc:1305511] |
| Ensembl ID | ENSRNOG00000002930 |
| Bio databases IDs | |
| Aliases | periplakin |
| Synonyms | periplakin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- SH3 domain
- PspA/IM30 family
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- structural constituent of cytoskeleton
- rod domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- cancer
- lung carcinoma
- seborrheic keratosis
- prostate cancer
- prostatic carcinoma
- epithelial cancer
- lung carcinoma process
- idiopathic inflammatory myopathy
regulates
- PI3K (complex)
- EVPL
- LORICRIN
role in cell
- proliferation
- formation
- assembly
- production
- cross-linkage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cytoskeleton
- cellular membrane
- Plasma Membrane
- Mitochondria
- desmosomes
- cell-cell contacts
- cytosol
- vimentin filaments
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing
- intermediate filament cytoskeleton organization
- keratinization
- response to mechanical stimulus
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- desmosome
- intermediate filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- structural molecule activity
- structural constituent of cytoskeleton