Evpl Gene Summary [Rat]
Predicted to enable structural molecule activity. Predicted to be involved in several processes, including intermediate filament cytoskeleton organization; keratinocyte differentiation; and peptide cross-linking. Predicted to act upstream of or within regulation of antibacterial peptide production. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be active in cornified envelope and cytoplasm. Predicted to colocalize with intermediate filament. Orthologous to human EVPL (envoplakin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Evpl |
| Official Name | envoplakin [Source:RGD Symbol;Acc:1306141] |
| Ensembl ID | ENSRNOG00000009343 |
| Bio databases IDs | |
| Aliases | envoplakin |
| Synonyms | ENVOPLAKIN, EVPK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Evpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- SPEC
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- SH3 domain
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- helix-rich Mycoplasma protein
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- Spectrin repeats
- Plectin repeat
- Intermediate filament protein
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- intermediate filament cytoskeleton
- Cytoplasm
- intermediate filaments
- desmosomes
- cell-cell contacts
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Evpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of antibacterial peptide production
- keratinocyte differentiation
- wound healing
- intermediate filament cytoskeleton organization
- epidermis development
- peptide cross-linking
- keratinization
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular vesicular exosome
- intermediate filament cytoskeleton
- cytoplasm
- membrane
- cytosol
- desmosome
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- structural molecule activity