Loxl2 Gene Summary [Rat]
Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; peptidyl-lysine oxidation; and positive regulation of cell differentiation. Located in basement membrane. Orthologous to human LOXL2 (lysyl oxidase like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Loxl2 |
| Official Name | lysyl oxidase-like 2 [Source:RGD Symbol;Acc:1308435] |
| Ensembl ID | ENSRNOG00000016758 |
| Bio databases IDs | |
| Aliases | lysyl oxidase-like 2 |
| Synonyms | LOR, LOR2, Lox2, lysyl oxidase-like 2, WS9-14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loxl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Scavenger receptor cysteine-rich domain
- protein-lysine 6-oxidase
- calcium ion binding
- enzyme
- protein binding
- Lysyl oxidase
- carbohydrate binding
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- COVID-19
- breast cancer
- colon cancer
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- metastasis
- chondrosarcoma
role in cell
- differentiation
- expression in
- migration
- formation
- formation in
- phosphorylation in
- proliferation
- cell viability
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- extracellular vesicles
- Extracellular Space
- Endoplasmic Reticulum
- nucleoplasm
- perinuclear space
- chromatin
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loxl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- protein modification process
- sprouting angiogenesis
- response to copper ion
- endothelial cell migration
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- peptidyl-lysine oxidation
- endothelial cell proliferation
- epithelial to mesenchymal transition
- positive regulation of chondrocyte differentiation
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- basement membrane
- membrane
- endoplasmic reticulum
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- protein binding
- copper ion binding
- calcium ion binding
- protein-lysine 6-oxidase activity