Dusp12 Gene Summary [Rat]
Enables kinase binding activity and phosphoprotein phosphatase activity. Involved in positive regulation of glucokinase activity and protein dephosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp12 |
| Official Name | dual specificity phosphatase 12 [Source:RGD Symbol;Acc:68375] |
| Ensembl ID | ENSRNOG00000003100 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 12 |
| Synonyms | 1190004O14Rik, dual specificity phosphatase 12, DUSP1, ESTM36, GKAP, LMW-DSP4, mVH1, T-DSP4, VH1, YVH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein tyrosine/serine/threonine phosphatase
- kinase binding
- zinc ion binding
- protein-tyrosine-phoshatase
- protein phosphatase
- phosphoprotein phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
Pathways
Biological processes and signaling networks where the Dusp12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- synapse
- postsynaptic density
- excitatory synapses
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein dephosphorylation
- dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein tyrosine phosphatase activity
- phosphatase activity
- kinase binding
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity