Eif5 Gene Summary [Rat]
Enables eukaryotic initiation factor eIF2 binding activity and translation initiation factor activity. Involved in activation of GTPase activity and formation of translation preinitiation complex. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif5 |
| Official Name | eukaryotic translation initiation factor 5 [Source:RGD Symbol;Acc:619861] |
| Ensembl ID | ENSRNOG00000010218 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 5 |
| Synonyms | 2810011H21RIK, D12Ertd549e, EIF-5A, eukaryotic translation initiation factor 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in IF2B/IF5
- eIF4-gamma/eIF5/eIF2-epsilon
- translation initiation factor
- protein binding
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- translation regulator
Pathways
Biological processes and signaling networks where the Eif5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- aortic valve calcification
- psoriasis
regulated by
- dexamethasone
- sirolimus
- tretinoin
- TP53
- empagliflozin
- megakaryocytes
- ritonavir
- CK2
- eprenetapopt
- troglitazone
regulates
- NFkB (complex)
- guanosine triphosphate
- IKB
- HSP27
- EIF
- L-methionyl-tRNA(Met)
role in cell
- expression in
- proliferation
- processing in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- synapse
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- ribosome assembly
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- protein binding
- eukaryotic initiation factor eIF2 binding
- GDP-dissociation inhibitor activity
- RNA binding
- cadherin binding
- GTPase activator activity