Zfp496 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF496 (zinc finger protein 496). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp496 |
| Official Name | zinc finger protein 496 [Source:RGD Symbol;Acc:1304611] |
| Ensembl ID | ENSRNOG00000003129 |
| Bio databases IDs | |
| Aliases | zinc finger protein 496 |
| Synonyms | NIZP1, ZFP496, zinc finger protein 496, zinc finger with KRAB and SCAN domains 17, ZKSCAN17, ZSCAN49 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp496 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- leucine rich region
- krueppel associated box
- zinc finger
- transcription regulator
- Drought induced 19 protein (Di19), zinc-binding
- Zinc-finger double domain
- SCAN domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
- DNA binding
- C2HR zinc finger domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp496 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity