N6amt1 Gene Summary [Rat]
Predicted to enable S-adenosyl-L-methionine binding activity and S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in several processes, including arsonoacetate metabolic process; epigenetic regulation of gene expression; and peptidyl-glutamine methylation. Predicted to act upstream of or within positive regulation of cell growth. Predicted to be located in nucleus. Predicted to be part of eRF1 methyltransferase complex. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | N6amt1 |
| Official Name | N-6 adenine-specific DNA methyltransferase 1 [Source:RGD Symbol;Acc:1311843] |
| Ensembl ID | ENSRNOG00000001603 |
| Bio databases IDs | |
| Aliases | N-6 adenine-specific DNA methyltransferase 1 |
| Synonyms | 5830445C04Rik, C21orf127, HEMK2, KMT9, m.HsaHemK2P, MTQ2, N-6 adenine-specific DNA methyltransferase 1, N-6 adenine-specific DNA methyltransferase 1 (putative), N6AMT, PRED28, PrmC, RGD1311843 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat N6amt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- protein methyltransferase
- histone methyltransferase
- binding protein
- enzyme
- site-specific DNA-methyltransferase (adenine-specific)
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
- N-methyltransferase
- arsenite methyltransferase
Pathways
Biological processes and signaling networks where the N6amt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- neoplasia
- liver cancer
- tumorigenesis
- gastric cancer
- colorectal cancer
- colorectal neoplasia
- gastrointestinal neoplasia
role in cell
- apoptosis
- expression in
- accumulation in
- growth
- migration
- proliferation
- accumulation
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat N6amt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell growth
- negative regulation of gene expression, epigenetic
- positive regulation of gene expression, epigenetic
- peptidyl-glutamine methylation
- arsonoacetate metabolic process
- toxin metabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- eRF1 methyltransferase complex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- protein methyltransferase activity
- protein-glutamine N-methyltransferase activity
- arsenite methyltransferase activity
- S-adenosylmethionine-dependent methyltransferase activity
- site-specific DNA-methyltransferase (adenine-specific) activity