Sdhc Gene Summary [Rat]
Predicted to enable heme binding activity and protein-membrane adaptor activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdhc |
| Official Name | succinate dehydrogenase complex subunit C [Source:RGD Symbol;Acc:1359454] |
| Ensembl ID | ENSRNOG00000003163 |
| Bio databases IDs | |
| Aliases | succinate dehydrogenase complex subunit C |
| Synonyms | 0610010E03Rik, CYB560, CYBL, PGL3, PPGL3, QPs-1, SDH3, succinate dehydrogenase complex subunit C, succinate dehydrogenase complex, subunit C, integral membrane protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdhc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SQR_QFR_TM
- protein binding activity, bridging
- enzyme
- protein binding
- heme binding
- succinate dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Sdhc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary paraganglioma-pheochromocytoma syndrome
- hereditary cancer-predisposing syndrome
- paraganglioma type 3
- paraganglioma
- paraganglioma formation
- Alzheimer disease
- Carney-Stratakis syndrome
- Carney triad
- chromophobe renal cell carcinoma
- chromophobe renal cancer
regulates
- reactive oxygen species
- succinate dehydrogenase
role in cell
- apoptosis
- accumulation in
- generation in
- respiration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdhc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial electron transport, succinate to ubiquinone
- tricarboxylic acid cycle
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex II
- mitochondrion
- membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- electron carrier activity
- heme binding