Fbf1 Gene Summary [Rat]
Predicted to be involved in apical junction assembly; cilium assembly; and establishment of epithelial cell polarity. Predicted to be located in apical junction complex; cilium; and cytoskeleton. Predicted to be part of ciliary transition fiber. Predicted to be active in centriole and ciliary basal body. Orthologous to human FBF1 (Fas binding factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbf1 |
| Official Name | Fas binding factor 1 [Source:RGD Symbol;Acc:1310662] |
| Ensembl ID | ENSRNOG00000008577 |
| Bio databases IDs | |
| Aliases | Fas binding factor 1 |
| Synonyms | 1110033G01Rik, 5930413D20, Alb, Albatross, Fas binding factor 1, mKIAA1863 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Domain of unknown function (DUF4659)
- Domain of unknown function (DUF4686)
- Ezrin/radixin/moesin, alpha-helical domain
- Trichohyalin-plectin-homology domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Family of unknown function (DUF5401)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- weight loss
- white matter hyperintensities
role in cell
- expression in
- assembly
- biogenesis
- senescence
- biogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ciliary transition fiber
- cilia
- basal bodies
- centrosome
- centriole
- intercellular junctions
- cytosol
- spindle pole
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- apical junction assembly
- establishment of epithelial cell polarity
Cellular Component
Where in the cell the gene product is active
- centrosome
- keratin filament
- centriole
- cilium basal body
- apical junction complex
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding