Maml1 Gene Summary [Rat]
Predicted to enable peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including atrioventricular node cell development; positive regulation of myotube differentiation; and positive regulation of transcription of Notch receptor target. Predicted to act upstream of or within Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Predicted to be active in nucleoplasm. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maml1 |
| Official Name | mastermind-like transcriptional coactivator 1 [Source:RGD Symbol;Acc:1308631] |
| Ensembl ID | ENSRNOG00000003268 |
| Bio databases IDs | |
| Aliases | mastermind-like transcriptional coactivator 1 |
| Synonyms | D930008C07RIK, Mam-1, mastermind-like transcriptional coactivator 1, mKIAA0200 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Maml1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MamL-1 domain
- activation domain
- transcription regulator
- transcription co-activator
- protein kinase binding
- protein binding
- basic domain
- peptide antigen binding
Pathways
Biological processes and signaling networks where the Maml1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- tumorigenesis
- rheumatic fever
- insomnia
- rotator cuff injury
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hyperplasia
- muscular dystrophy
- experimental autoimmune encephalomyelitis
role in cell
- expression in
- differentiation
- proliferation
- phosphorylation in
- size
- cell death
- accumulation
- number
- formation
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Maml1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- atrioventricular node cell development
- positive regulation of myotube differentiation
- myoblast differentiation
- atrioventricular node development
- positive regulation of transcription of Notch receptor target
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- MAML1-RBP-Jkappa- ICN1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- peptide antigen binding
- transcription coactivator activity