Il7r Gene Summary [Rat]
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Il7r |
| Official Name | interleukin 7 receptor [Source:RGD Symbol;Acc:1309776] |
| Ensembl ID | ENSRNOG00000058446 |
| Bio databases IDs | |
| Aliases | interleukin 7 receptor |
| Synonyms | CD127, CDW127, IL7RA, IL-7R-alpha, IL-7 receptor alpha CHAIN, IL-7 receptor α CHAIN, IL-7R-α, ILRA, IMD104, interleukin 7 receptor, LOC100911254, sIL-7R |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il7r often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- PPXY motif
- antigen binding
- interleukin-7 receptor
- protein binding
- acidic domain
- Fibronectin type III domain
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il7r gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- septic shock
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive
- sepsis
- severe combined immunodeficiency
- primary biliary cirrhosis
- rheumatoid arthritis
- neoplastic cell transformation
- IgA nephropathy
role in cell
- apoptosis
- activation in
- production in
- cell death
- phosphorylation in
- proliferation
- growth
- survival
- expression in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- plasma membrane extracellular face
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il7r gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell differentiation in thymus
- hemopoiesis
- interleukin-7-mediated signaling pathway
- regulation of cell size
- positive regulation of cell proliferation
- lymph node development
- regulation of DNA recombination
- T cell homeostasis
- immune response
- cytokine-mediated signaling pathway
- defense response to Gram-positive bacterium
- cellular homeostasis
- T cell differentiation in thymus
- signal transduction
- cell morphogenesis
- B cell proliferation
- cell surface receptor signaling pathway
- B cell homeostasis
- positive regulation of JAK-STAT cascade
- negative regulation of T cell apoptotic process
- positive regulation of gene expression
- T cell mediated cytotoxicity
- gene expression
- negative regulation of T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- clathrin-coated endocytic vesicle membrane
- external side of plasma membrane
- cytosol
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- antigen binding
- interleukin-7 receptor activity
- cytokine receptor activity