Tmem63a Gene Summary [Rat]
Predicted to enable calcium-activated cation channel activity; mechanosensitive monoatomic ion channel activity; and osmolarity-sensing monoatomic cation channel activity. Predicted to be involved in surfactant secretion. Predicted to be located in centriolar satellite; early endosome membrane; and lysosomal membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 19. Orthologous to human TMEM63A (transmembrane protein 63A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem63a |
| Official Name | transmembrane protein 63a [Source:RGD Symbol;Acc:1306829] |
| Ensembl ID | ENSRNOG00000003310 |
| Bio databases IDs | |
| Aliases | transmembrane protein 63a |
| Synonyms | BC014795, HLD19, KIAA0792, RGD1306829, Tmem6, Tmem64a, transmembrane protein 63A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem63a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- osmosensor
- Calcium-dependent channel, 7TM region, putative phosphate
- channel/pore class transporter
- Late exocytosis, associated with Golgi transport
- inorganic uptake permease
- protein binding
- mechanically-gated ion channel
- Cytosolic domain of 10TM putative phosphate transporter
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- centrosome
- tertiary granule membrane
- specific granule membrane
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem63a gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- centriolar satellite
- tertiary granule membrane
- plasma membrane
- lysosomal membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- calcium activated cation channel activity
- mechanically-gated ion channel activity
- protein binding