Pip4p1 Gene Summary [Rat]
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in several processes, including phosphatidylinositol dephosphorylation; positive regulation of TORC1 signaling; and proton-transporting V-type ATPase complex assembly. Predicted to be active in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pip4p1 |
| Official Name | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [Source:RGD Symbol;Acc:1307475] |
| Ensembl ID | ENSRNOG00000009948 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 |
| Synonyms | BC039161, C14orf9, LOC100366257, phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1, PTDINS-4,5-P2 4-PTASE I, PTDINS-4,5-P2 4-PTASE type I, RGD1307475, TMEM55B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pip4p1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 55A
- phosphatase
- protein binding
- phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- chronic lymphocytic leukemia
regulated by
- lipopolysaccharide
- cisplatin
- TFEB
- eltrombopag
- trichostatin A
- topotecan
regulates
- phosphatidylinositol 4,5-bisphosphate
- EGFR
- cholesterol
- phosphatidylinositol
- phosphtidylinositol 5-phosphate
- phospholipid
role in cell
- morphology
- transport in
- localization
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- endosomes
- lysosome
- lysosome membrane
- endosomal membrane
- nucleoplasm
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pip4p1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- cholesterol metabolic process
- response to sterol depletion
- phospholipid metabolic process
- proton-transporting V-type ATPase complex assembly
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- phagocytic vesicle membrane
- plasma membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity