Ergic1 Gene Summary [Rat]
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and nucleoplasm. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in neurogenic-type arthrogryposis multiplex congenita-2. Orthologous to human ERGIC1 (endoplasmic reticulum-golgi intermediate compartment 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ergic1 |
| Official Name | endoplasmic reticulum-golgi intermediate compartment 1 [Source:RGD Symbol;Acc:1585015] |
| Ensembl ID | ENSRNOG00000003508 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum-golgi intermediate compartment 1 |
| Synonyms | 1200007D18Rik, AMC2, AMCN, endoplasmic reticulum-golgi intermediate compartment 1, ERGIC-32, KIAA1181, LOC100364400, LOC682838, maa-136, NET24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ergic1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
- Endoplasmic reticulum vesicle transporter
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurogenic arthrogryposis multiplex congenita
- colorectal cancer
- amyotrophic lateral sclerosis
- frontotemporal dementia
- ulcerative colitis
- inflammatory bowel disease
- Crohn disease
- tumorigenesis
- susceptibility to amyotrophic lateral sclerosis
- periodontitis
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cellular membrane
- Nucleus
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ergic1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- ER to Golgi transport vesicle
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding