Lemd3 Gene Summary [Rat]
Predicted to enable chromatin DNA binding activity. Predicted to be involved in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway and nuclear envelope organization. Predicted to act upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Predicted to be located in nuclear inner membrane. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lemd3 |
| Official Name | LEM domain containing 3 [Source:RGD Symbol;Acc:1596822] |
| Ensembl ID | ENSRNOG00000024027 |
| Bio databases IDs | |
| Aliases | LEM domain containing 3 |
| Synonyms | LEM domain containing 3, MAN1, Msrb3, RGD1561001 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lemd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- LEM
- protein binding
- LEM domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatofibrosis lenticularis disseminata
- melorheostosis with osteopoikilosis
- hereditary disorder
- Tietze disease
- osteopoikilosis
- venous thromboembolism
- intracranial arteriovenous malformation
role in cell
- differentiation
- organization
- cell cycle progression
- myogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- inner nuclear membrane
- nuclear envelope
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lemd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of activin receptor signaling pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding