Tom1l2 Gene Summary [Rat]
Predicted to enable clathrin binding activity and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division and signal transduction. Predicted to be active in endosome and membrane. Orthologous to human TOM1L2 (target of myb1 like 2 membrane trafficking protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tom1l2 |
| Official Name | target of myb1 like 2 membrane trafficking protein [Source:RGD Symbol;Acc:1306728] |
| Ensembl ID | ENSRNOG00000003590 |
| Bio databases IDs | |
| Aliases | target of myb1 like 2 membrane trafficking protein |
| Synonyms | 2900016I08Rik, A730055F12Rik, LOC246315, Srebf1, target of myb1-like 2 (chicken), target of myb1 like 2 membrane trafficking protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tom1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- protein kinase binding
- clathrin box motif
- VHS, ENTH and ANTH domain superfamily
- clathrin binding
- protein binding
- GAT domain
- transporter
- Domain present in VPS-27, Hrs and STAM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- prostate cancer
- myocardial infarction
- colorectal cancer
- prostatic carcinoma
- dementia
- streptococcal pharyngitis
regulated by
- RBM25
- memantine
- WWP2
- crizotinib
role in cell
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tom1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- signal transduction
- protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- clathrin binding