Tom1l2 Gene Summary [Mouse]
Predicted to enable clathrin binding activity and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division and signal transduction. Predicted to be active in endosome and membrane. Orthologous to human TOM1L2 (target of myb1 like 2 membrane trafficking protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tom1l2 |
| Official Name | target of myb1-like 2 (chicken) [Source:MGI Symbol;Acc:MGI:2443306] |
| Ensembl ID | ENSMUSG00000000538 |
| Bio databases IDs | |
| Aliases | target of myb1-like 2 (chicken) |
| Synonyms | 2900016I08Rik, A730055F12Rik, LOC246315, Srebf1, target of myb1-like 2 (chicken), target of myb1 like 2 membrane trafficking protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tom1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- protein kinase binding
- clathrin box motif
- VHS, ENTH and ANTH domain superfamily
- clathrin binding
- protein binding
- GAT domain
- transporter
- Domain present in VPS-27, Hrs and STAM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- prostate cancer
- myocardial infarction
- colorectal cancer
- prostatic carcinoma
- dementia
- streptococcal pharyngitis
phenotypes
- abnormal cornea morphology
- abnormal eye distance/ position
- abnormal fear/anxiety-related behavior
- abnormal humoral immune response
- abnormal immune system physiology
- abnormal inflammatory response
- abnormal lymph node cell ratio
- abnormal spleen B cell follicle morphology
- abnormal spleen morphology
- abnormal spleen periarteriolar lymphoid sheath morphology
- abnormal splenic cell ratio
- conjunctivitis
- dermatitis
- emphysema
- enlarged spleen
- exophthalmos
- focal hair loss
- hemorrhage
- hydrocephaly
- hyperactivity
- increased B cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased T cell number
- increased adenoma incidence
- increased basal cell carcinoma incidence
- increased inflammatory response
- increased leukocyte cell number
- increased lung tumor incidence
- increased mammary gland tumor incidence
- increased metastatic potential
- increased ovary tumor incidence
- increased prostate gland tumor incidence
- increased skin tumor incidence
- increased spleen white pulp amount
- increased susceptibility to bacterial infection
- increased susceptibility to infection
- increased total body fat amount
- increased tumor incidence
- increased vertical activity
- kidney cysts
- kyphosis
- lymphoid hyperplasia
- malocclusion
- ovary cysts
- skin lesions
- spontaneous skin ulceration
- thrombocytopenia
role in cell
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tom1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- signal transduction
- protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- endosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- clathrin binding