Cav1 Gene Summary [Rat]
Enables several functions, including enzyme binding activity; syntaxin binding activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cation transmembrane transport; positive regulation of cellular component organization; and regulation of endothelial cell proliferation. Located in several cellular components, including basal plasma membrane; focal adhesion; and peroxisomal membrane. Part of protein-containing complex. Biomarker of several diseases, including artery disease (multiple); brain ischemia (multiple); obesity; osteoarthritis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cav1 |
| Official Name | caveolin 1 [Source:RGD Symbol;Acc:2280] |
| Ensembl ID | ENSRNOG00000056836 |
| Bio databases IDs | |
| Aliases | caveolin 1 |
| Synonyms | BSCL3, Cav, Cavelolin 1, CAVEOLIN, Caveolin1, caveolin 1, caveolae protein, CGL3, LCCNS, LOC100362870, MSTP085, PPH3, VIP21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cav1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- protein binding activity, bridging
- enzyme inhibitor activity
- protease activator
- identical protein binding
- syntaxin binding
- nitric oxide synthase regulator
- ion channel binding
- Src phosphorylation site
- transmembrane receptor
- oxysterol binding
- Caveolin
- palmitoylation site
- cholesterol binding
- protein kinase binding
- enzyme binding
- protein binding
- receptor binding
- Mdm2 protein binding domain
- potassium channel inhibitor
- phosphorylation site
- caveolin-scaffolding domain
- ATPase binding
- binding protein
- kinase binding
- protein tyrosine kinase inhibitor activity
- transmembrane domain
- protein heterodimerization
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Cav1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Caveolar-mediated Endocytosis Signaling
- eNOS Signaling
- Estrogen Receptor Signaling
- G Beta Gamma Signaling
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- Integrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- PDGF Signaling
- Serotonin Receptor Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- neoplasia
- metastasis
- esophageal adenocarcinoma
- gastric cancer
- experimental autoimmune encephalomyelitis
- ovarian cancer
- hyperplasia
- Alzheimer disease
- experimental silicosis
role in cell
- production in
- expression in
- molecular cleavage in
- degradation in
- activation in
- growth
- cell death
- phosphorylation in
- ubiquitination in
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- microsomal fraction
- plasma membrane fraction
- raft fractions
- caveolae fraction
- soluble fraction
- endoplasmic reticulum fraction
- plasma membrane peroxisome fraction
- Golgi-enriched fraction
- low-density microsomal fraction
- detergent-insoluble fractions
- membrane fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- caveosome
- prostasome
- perinuclear body
- viral bud
- endocytic vesicle membrane
- exocytic vesicle
- cytoskeleton
- Cytoplasm
- invadopodia
- cilia
- perinuclear Golgi regions
- cell surface
- pericentrosomal region
- cell borders
- perijunctional region
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- inner membrane
- focal adhesions
- Golgi apparatus component
- cell cortex
- Nucleus
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- actin filaments
- intercellular junctions
- cell-cell contacts
- lipid droplets
- granules
- cytoplasmic aggregates
- perinucleolar foci
- cytosol
- basal cell surfaces
- basolateral cell surfaces
- endoplasmic reticulum membrane
- microsome
- caveolar membranes
- caveola necks
- apical membrane
- caveolae
- synaptic membrane
- plasma membrane projections
- basolateral membrane
- basal membrane
- cell membrane-lagging edges
- Golgi membrane
- trans Golgi network
- peroxisome membrane
- endosomal membrane
- acrosome
- growth cone
- neurites
- synaptosomes
- photoreceptor inner segments
- cytoplasmic vesicles
- endocytotic vesicle
- peroxisomes
- transverse tubules
- storage granules
- membrane rafts
- detergent insoluble microdomains
- microvilli
- cell membrane leading edge
- perikaryon
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cav1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- response to estrogen stimulus
- regulation of blood coagulation
- negative regulation of protein tyrosine kinase activity
- protein transport
- response to progesterone stimulus
- protein localization
- triglyceride metabolic process
- negative regulation of tyrosine phosphorylation of STAT protein
- regulation of the force of heart contraction by chemical signal
- response to hypoxia
- vesicle organization
- caveolin-mediated endocytosis
- cellular response to peptide hormone stimulus
- positive regulation of protein ubiquitination
- negative regulation of peptidyl-serine phosphorylation
- cellular response to hyperoxia
- establishment of localization in cell
- negative regulation of protein ubiquitination
- cholesterol transport
- positive regulation of intrinsic apoptotic signaling pathway
- cellular response to misfolded protein
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of toll-like receptor 3 signaling pathway
- caveola assembly
- positive regulation of cell adhesion molecule production
- regulation of ruffle assembly
- negative regulation of JAK-STAT cascade
- negative regulation of nitric oxide biosynthetic process
- cellular response to transforming growth factor beta stimulus
- negative regulation of epithelial cell differentiation
- cellular response to exogenous dsRNA
- positive regulation of catalytic activity
- positive regulation of gene expression
- regulation of heart rate by cardiac conduction
- nitric oxide biosynthetic process
- membrane depolarization
- receptor internalization
- positive regulation of cell migration
- regulation of peptidase activity
- muscle cell homeostasis
- insulin receptor internalization
- calcium ion homeostasis
- negative regulation of MAPK cascade
- nitric oxide homeostasis
- positive regulation of vasoconstriction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- apoptotic signaling pathway
- lactation
- vasoconstriction
- vasculogenesis
- cholesterol homeostasis
- glandular epithelial cell differentiation
- regulation of smooth muscle contraction
- negative regulation of necroptosis
- negative regulation of cytokine-mediated signaling pathway
- fibroblast proliferation
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- maintenance of protein location in cell
- response to ischemia
- negative regulation of anoikis
- viral entry into host cell via receptor-mediated endocytosis
- angiogenesis
- negative regulation of fibroblast proliferation
- cytokine-mediated signaling pathway
- calcium ion transport
- positive regulation of cholesterol efflux
- canonical Wnt receptor signaling pathway
- basement membrane organization
- regulation of entry of bacterium into host cell
- mammary gland involution
- negative regulation of peptidyl-tyrosine autophosphorylation
- T cell costimulation
- angiotensin-mediated signaling pathway
- cytosolic calcium ion homeostasis
- cellular calcium ion homeostasis
- negative regulation of canonical Wnt receptor signaling pathway
- posttranscriptional regulation of gene expression
- negative regulation of pinocytosis
- response to bacterium
- mammary gland development
- skeletal muscle tissue development
- response to calcium ion
- endothelial cell proliferation
- cell differentiation
- negative regulation of endothelial cell proliferation
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of calcium ion transport into cytosol
- regulation of fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- acrosomal membrane
- caveolar macromolecular signaling complex
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- endoplasmic reticulum membrane
- early endosome membrane
- lipid particle
- caveola
- endosome
- perinuclear region of cytoplasm
- focal adhesion
- sarcolemma
- cell cortex
- membrane
- membrane raft
- cilium
- cytoplasmic vesicle
- macromolecular complex
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- peptidase activator activity
- cholesterol binding
- protein tyrosine kinase inhibitor activity
- oxysterol binding
- patched binding
- receptor binding
- ion channel binding
- protein binding
- inward rectifier potassium channel inhibitor activity
- protein heterodimerization activity
- small GTPase binding
- protein binding, bridging
- nitric-oxide synthase binding
- ATPase binding
- enzyme binding
- binding, bridging