Laptm5 Gene Summary [Rat]
Predicted to enable protein sequestering activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including lysosomal transport; regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Located in lysosome. Orthologous to human LAPTM5 (lysosomal protein transmembrane 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Laptm5 |
| Official Name | lysosomal protein transmembrane 5 [Source:RGD Symbol;Acc:621838] |
| Ensembl ID | ENSRNOG00000011054 |
| Bio databases IDs | |
| Aliases | lysosomal protein transmembrane 5 |
| Synonyms | CLAST6, E3, gcd-10, KIAA0085, lysosomal-associated protein transmembrane 5, lysosomal protein transmembrane 5, Lysosome-associated protein transmembrane 5, Stra13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Laptm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Golgi 4-transmembrane spanning transporter
- ubiquitin protein ligase binding
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- peripheral arterial disease
- tumorigenesis
- hepatic fibrosis
- diabetic nephropathy
- hepatic injury
- lichen planus
- familial Waldenstrom macroglobulinemia
- delayed hypersensitive reaction
- androgenic alopecia
role in cell
- proliferation
- expression in
- activation
- apoptosis
- cellular infiltration by
- phosphorylation in
- tumorsphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- lysosome
- trans Golgi network
- lysosome membrane
- transport vesicles
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Laptm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of MAPK cascade
- intracellular protein transport
- protein targeting to lysosome
- Golgi to lysosome transport
- positive regulation of macrophage cytokine production
- positive regulation of cytokine production involved in immune response
- defense response to tumor cell
- positive regulation of interleukin-12 production
- negative regulation of interleukin-2 production
- negative regulation of T cell receptor signaling pathway
- positive regulation of receptor catabolic process
- positive regulation of lysosomal membrane permeability
- positive regulation of protein ubiquitination
- negative regulation of B cell activation
- induction of programmed cell death
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of T cell activation
- negative regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasmic vesicle
- cytosol
- macromolecular complex
- transport vesicle
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding