Ufc1 Gene Summary [Rat]
Predicted to enable UFM1 conjugating enzyme activity. Predicted to be involved in several processes, including protein K69-linked ufmylation; regulation of type II interferon production; and reticulophagy. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ufc1 |
| Official Name | ubiquitin-fold modifier conjugating enzyme 1 [Source:RGD Symbol;Acc:1303313] |
| Ensembl ID | ENSRNOG00000003706 |
| Bio databases IDs | |
| Aliases | ubiquitin-fold modifier conjugating enzyme 1 |
| Synonyms | 1110021H02Rik, ESTM29, HSPC155, NEDSG, ubiquitin-fold modifier conjugating enzyme 1, ufc1-s |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ufc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-like protein transferase activity
- Ubiquitin-fold modifier-conjugating enzyme 1
- UBCc_UEV
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neurodevelopmental disorder with spasticity and poor growth
regulated by
- tunicamycin
- thapsigargin
- lactic acid
role in cell
- expression in
- activation in
- amplification
- amplification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ufc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of interferon-gamma production
- brain development
- response to endoplasmic reticulum stress
- protein ufmylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- UFM1 conjugating enzyme activity