Tbl1x Gene Summary [Rat]
Predicted to enable several functions, including histone binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; protein stabilization; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including fat cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to estrogen. Predicted to be located in mitotic spindle and nucleus. Predicted to be part of histone deacetylase complex and transcription repressor complex. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1X (transducin beta like 1 X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbl1x |
| Official Name | transducin (beta)-like 1 X-linked [Source:RGD Symbol;Acc:1563868] |
| Ensembl ID | ENSRNOG00000003686 |
| Bio databases IDs | |
| Aliases | transducin (beta)-like 1 X-linked |
| Synonyms | CHNG8, EBI, RGD1563868, SMAP55, TBL1, transducin (beta)-like 1 X-linked, transducin beta like 1 X-linked, transducin (β)-like 1 X-linked, transducin β like 1 X-linked |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbl1x often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- Eukaryotic translation initiation factor eIF2A
- N-cor and Gps2 binding domain
- nucleic acid binding
- transcription co-repressor
- WD domain, G-beta repeat
- chromatin binding
- WD40
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- double-stranded DNA binding
- LisH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- breast carcinoma
- endometrial cancer
- adenomyosis
- systemic lupus erythematosus
- nongoitrous congenital hypothyroidism type 8
- non-insulin-dependent diabetes mellitus
- uterine leiomyoma
- leiomyomatosis
role in cell
- differentiation
- binding in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbl1x gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transcription, DNA-dependent
- proteolysis
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- protein stabilization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- transcriptional repressor complex
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- histone binding
- transcription regulatory region sequence-specific DNA binding