Nr0b1 Gene Summary [Rat]
Enables double-stranded DNA binding activity and sequence-specific DNA binding activity. Involved in several processes, including regulation of DNA-templated transcription; response to benzoic acid; and response to retinoic acid. Predicted to be located in several cellular components, including centriolar satellite; nuclear speck; and ribosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in 46,XY sex reversal 2 and X-linked adrenal hypoplasia congenita. Orthologous to human NR0B1 (nuclear receptor subfamily 0 group B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr0b1 |
| Official Name | nuclear receptor subfamily 0, group B, member 1 [Source:RGD Symbol;Acc:62028] |
| Ensembl ID | ENSRNOG00000003765 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 0, group B, member 1 |
| Synonyms | AHC, AHCH, AHX, DAX-1, DSS, GTD, HHG, mDax1-134, mDax1-218, mDax1-225, mDax1-249, mDax1-292, mDax1-297, mDax1-300, mDax1-308, mDax1-318, mDax1-329, mDax1-337, mDax1-344, mDax1-38, mDax1-404, mDax1-472, NROB1, nuclear receptor subfamily 0 group B member 1, nuclear receptor subfamily 0, group B, member 1, SRXY2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nr0b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silencing domain
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- AF-2 domain binding
- DNA binding domain
- transcription co-repressor
- DNA secondary structure binding
- transcription factor binding
- AF-2 transcription activation domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- nuclear receptor ligand binding domain
- transcription repression domain
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- protein homodimerization
- Ligand-binding domain of nuclear hormone receptor
- Nuclear receptor repeat
Pathways
Biological processes and signaling networks where the Nr0b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- familial X-linked adrenal hypoplasia congenita
- congenital hypoplasia of adrenal gland
- hyperplasia
- hypogonadotropic hypogonadism
- neoplastic cell transformation
- acne
- uterine leiomyoma
- leiomyomatosis
regulates
- reactive oxygen species
- JNK
- triacylglycerol
- PEPCK
- lipid
- D-glucose
- SREBF1
- glutathione
- G6PC1
- ACAC
role in cell
- expression in
- quantity
- activation in
- differentiation
- formation
- motility
- number
- development
- pluripotency
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- perichromatin fibril
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- ribosome
- centrosome
- polysomes
- nuclear pores
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nr0b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- negative regulation of intracellular steroid hormone receptor signaling pathway
- spermatogenesis
- Sertoli cell differentiation
- protein localization
- hypothalamus development
- negative regulation of sequence-specific DNA binding transcription factor activity
- pituitary gland development
- negative regulation of transcription from RNA polymerase II promoter
- male sex determination
- gonad development
- negative regulation of transcription, DNA-dependent
- endodermal cell differentiation
- response to immobilization stress
- Leydig cell differentiation
- adrenal gland development
- negative regulation of steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nuclear speck
- centriolar satellite
- membrane
- ribosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein domain specific binding
- protein homodimerization activity
- RNA binding
- protein binding
- transcription corepressor activity
- transcription factor binding
- DNA hairpin binding