Cyp19a1 Gene Summary [Rat]
Enables aromatase activity. Involved in several processes, including gonad development; limbic system development; and steroid metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp19a1 |
| Official Name | cytochrome P450, family 19, subfamily a, polypeptide 1 [Source:RGD Symbol;Acc:2457] |
| Ensembl ID | ENSRNOG00000000196 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 19, subfamily a, polypeptide 1 |
| Synonyms | Ar, ArKO, ARO, ARO1, Aromatase, CPV1, CYAR, CYP19, Cyp19a, CYP19P1, CYPXIX, cytochrome P450 family 19 subfamily A member 1, cytochrome P450, family 19, subfamily a, polypeptide 1, Int-5, LOC100359906, P-450AROM, p450 aromatase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp19a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- electron carrier
- oxygen binding
- aromatase
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- enzyme
- steroid hydroxylase
- heme binding
Pathways
Biological processes and signaling networks where the Cyp19a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- weight gain
- hepatic steatosis
- obesity
- insulin resistance
- hyperglycemia
- invasive breast cancer
- metastatic invasive breast cancer
- malignant neoplasm of endometrium
role in cell
- apoptosis
- inhibition in
- number
- proliferation
- invasion by
- quantity
- expression in
- influx
- chemotaxis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular compartment
- presynaptic regions
- Golgi region
- intracellular space
- basal compartment
- perinuclear region
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- flagella
- endoplasmic reticulum membrane
- residual bodies
- dendritic spines
- synaptic vesicles
- rough endoplasmatic reticulum
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp19a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uterus development
- prostate gland growth
- steroid biosynthetic process
- female gonad development
- androgen catabolic process
- estrogen biosynthetic process
- negative regulation of chronic inflammatory response
- mammary gland development
- positive regulation of estradiol secretion
- syncytium formation
- response to estradiol stimulus
- testosterone biosynthetic process
- female genitalia development
- negative regulation of macrophage chemotaxis
- sterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- iron ion binding
- steroid hydroxylase activity
- electron carrier activity
- aromatase activity
- heme binding