Hscb Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in [2Fe-2S] cluster assembly and primitive erythrocyte differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia 5. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hscb |
| Official Name | HscB mitochondrial iron-sulfur cluster co-chaperone [Source:RGD Symbol;Acc:1311005] |
| Ensembl ID | ENSRNOG00000037508 |
| Bio databases IDs | |
| Aliases | HscB mitochondrial iron-sulfur cluster co-chaperone |
| Synonyms | DNAJC20, HSC20, HscB iron-sulfur cluster co-chaperone, HscB iron-sulphur cluster co-chaperone, HscB mitochondrial iron-sulfur cluster co-chaperone, HscB mitochondrial iron-sulphur cluster co-chaperone, JAC1, RGD1311005, SIDBA5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hscb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HSCB C-terminal oligomerization domain
- Fe-S protein assembly co-chaperone HscB
- Co-chaperone HscB tetracysteine metal binding motif
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Hscb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hscb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- [2Fe-2S] cluster assembly
- primitive erythrocyte differentiation
- protein oligomerization
- primitive hemopoiesis
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- chaperone binding
- ATPase activator activity