Wipi1 Gene Summary [Rat]
Predicted to enable several functions, including nuclear receptor binding activity; phosphatidylinositol phosphate binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including macroautophagy; positive regulation of autophagosome assembly; and vesicle targeting, trans-Golgi to endosome. Predicted to be located in bounding membrane of organelle; phagophore assembly site; and trans-Golgi network. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI1 (WD repeat domain, phosphoinositide interacting 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wipi1 |
| Official Name | WD repeat domain, phosphoinositide interacting 1 [Source:RGD Symbol;Acc:1307754] |
| Ensembl ID | ENSRNOG00000003827 |
| Bio databases IDs | |
| Aliases | WD repeat domain, phosphoinositide interacting 1 |
| Synonyms | 4930533H01Rik, ATG18, ATG18A, D11Ertd498e, FLJ10055, RGD1307754, WD repeat domain, phosphoinositide interacting 1, WIPI49 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wipi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- protein binding activity, bridging
- androgen receptor binding
- protein binding
- receptor binding
- estrogen receptor binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Wipi1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- major depression
- acute myocardial infarction
role in cell
- molecular cleavage in
- response
- assembly
- autophagy by
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endosomes
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- endosomal membrane
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wipi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- vesicle targeting, trans-Golgi to endosome
- protein localization to pre-autophagosomal structure
- autophagy
- peroxisome degradation
- protein lipidation
- positive regulation of autophagic vacuole assembly
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- cytoskeleton
- pre-autophagosomal structure membrane
- cytoplasm
- pre-autophagosomal structure
- cytosol
- Golgi membrane
- endosome membrane
- extrinsic to membrane
- clathrin-coated vesicle
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- androgen receptor binding
- phosphatidylinositol-3,5-bisphosphate binding
- estrogen receptor binding
- phosphatidylinositol-3-phosphate binding
- receptor binding
- protein binding, bridging