Tfeb

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; defense response to bacterium; and positive regulation of metabolic process. Predicted to act upstream of or within lysosome organization and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and lysosomal membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tfeb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tfeb gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Tfeb gene, providing context for its role in the cell.