C4bpb Gene Summary [Rat]
Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPB (complement component 4 binding protein beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C4bpb |
| Official Name | complement component 4 binding protein, beta [Source:RGD Symbol;Acc:2236] |
| Ensembl ID | ENSRNOG00000004125 |
| Bio databases IDs | |
| Aliases | complement component 4 binding protein, beta |
| Synonyms | C4BP, C4bp-ps1, complement component 4 binding protein beta, complement component 4 binding protein, beta, complement component 4 binding protein β, complement component 4 binding protein, β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C4bpb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- alpha helix
- protein binding
- Sushi repeat (SCR repeat)
- SUSHI repeat
Pathways
Biological processes and signaling networks where the C4bpb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C4bpb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of complement activation, classical pathway
- complement activation, classical pathway
- innate immune response
- response to symbiotic bacterium
- positive regulation of protein catabolic process
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding