Slc7a3 Gene Summary [Rat]
Enables L-arginine transmembrane transporter activity; L-lysine transmembrane transporter activity; and L-ornithine transmembrane transporter activity. Involved in carboxylic acid transport and regulation of TOR signaling. Predicted to be active in plasma membrane. Orthologous to human SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Slc7a3 |
| Official Name | solute carrier family 7 member 3 [Source:RGD Symbol;Acc:68342] |
| Ensembl ID | ENSRNOG00000004133 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 3 |
| Synonyms | ATRC3, CAT-3, SLC7A1, SLC7A2, solute carrier family 7 (cationic amino acid transporter, y+ system), member 3, solute carrier family 7 member 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc7a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L-amino acid transporter
- protein binding
- basic amino acid transporter
- cationic amino acid transport permease
- organic cation transporter
- amino acid permease (GABA permease)
- amino acid permease (yeast)
- lysine transporter
- amino acid permease
- ornithine transporter
- L-type amino acid transporter
- C-terminus of AA_permease
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- preeclampsia
- hypothyroidism
- uterine leiomyoma
- leiomyomatosis
- yolk sac neoplasm
- germ cell neoplasia
regulates
- L-arginine
- arginine
- L-lysine
- amino acids
- L-Arg, L-Lys, L-Orn
- L-ornithine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc7a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amino acid transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-lysine transmembrane transporter activity
- L-ornithine transmembrane transporter activity
- amino acid transmembrane transporter activity