Epha1 Gene Summary [Rat]
Predicted to enable fibronectin binding activity; protein kinase binding activity; and transmembrane-ephrin receptor activity. Involved in positive regulation of angiogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human EPHA1 (EPH receptor A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha1 |
| Official Name | Eph receptor A1 [Source:RGD Symbol;Acc:1304680] |
| Ensembl ID | ENSRNOG00000017525 |
| Bio databases IDs | |
| Aliases | Eph receptor A1 |
| Synonyms | 5730453L17Rik, EPH, EPH1, EPH receptor A1, EPHT, EPHT1, Esk |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epha1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ephrin receptor
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- fibronectin binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- transmembrane-ephrin receptor
- Protein Kinases, catalytic domain
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Epha1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- Alzheimer disease
- endometriosis
- late-onset Alzheimer disease
- uterine serous papillary cancer
- early missed abortion
- hydronephrosis
- pathologic myopia
role in cell
- proliferation
- migration
- development
- collapse
- adhesion
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epha1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- multicellular organismal development
- positive regulation of cell proliferation
- protein autophosphorylation
- cell surface receptor signaling pathway
- negative regulation of protein kinase activity
- positive regulation of angiogenesis
- positive regulation of cell-matrix adhesion
- angiogenesis
- positive regulation of stress fiber assembly
- regulation of GTPase activity
- ephrin receptor signaling pathway
- substrate adhesion-dependent cell spreading
- positive regulation of kinase activity
- negative regulation of cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- transmembrane receptor protein tyrosine kinase activity
- fibronectin binding
- protein kinase activity
- transmembrane-ephrin receptor activity