Lrp12 Gene Summary [Rat]
Predicted to enable integrin binding activity. Predicted to act upstream of or within several processes, including generation of neurons; integrin activation; and lymphocyte migration into lymphoid organs. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 28 and oculopharyngodistal myopathy 1. Orthologous to human LRP12 (LDL receptor related protein 12). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp12 |
| Official Name | LDL receptor related protein 12 [Source:RGD Symbol;Acc:1304943] |
| Ensembl ID | ENSRNOG00000004152 |
| Bio databases IDs | |
| Aliases | LDL receptor related protein 12 |
| Synonyms | AI848829, ALS28, C820005L12Rik, LDL receptor related protein 12, low density lipoprotein-related protein 12, MIG13A, ST7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- integrin binding
- LDLa
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- amyotrophic lateral sclerosis type 28
- oculopharyngodistal myopathy type 1
regulates
- Integrin
role in cell
- migration
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrp12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- signal transduction
- neuron projection development
- endocytosis
- regulation of growth
Cellular Component
Where in the cell the gene product is active
- coated pit
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein receptor activity