LRP12 Gene Summary [Human]
This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | LRP12 |
| Official Name | LDL receptor related protein 12 [Source:HGNC Symbol;Acc:HGNC:31708] |
| Ensembl ID | ENSG00000147650 |
| Bio databases IDs | |
| Aliases | LDL receptor related protein 12 |
| Synonyms | AI848829, ALS28, C820005L12Rik, LDL receptor related protein 12, low density lipoprotein-related protein 12, MIG13A, ST7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRP12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- integrin binding
- LDLa
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- amyotrophic lateral sclerosis type 28
- oculopharyngodistal myopathy type 1
regulates
- Integrin
role in cell
- migration
- adhesion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRP12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- signal transduction
- neuron projection development
- endocytosis
- regulation of growth
Cellular Component
Where in the cell the gene product is active
- coated pit
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein receptor activity