Sybu Gene Summary [Rat]
Enables microtubule binding activity. Involved in several processes, including axonal transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic activity. Acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus. Located in dense body; microtubule; and vesicle. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sybu |
| Official Name | syntabulin [Source:RGD Symbol;Acc:1564335] |
| Ensembl ID | ENSRNOG00000004200 |
| Bio databases IDs | |
| Aliases | syntabulin |
| Synonyms | 5730410E15Rik, GOLSYN, OCSYN, RGD1564335, SNPHL, Syntabulin, syntabulin (syntaxin-interacting) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sybu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- KIF5B-binding domain
- Golgi-localized syntaxin-1-binding clamp
- protein binding
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- atopic dermatitis
- schizophrenia
- Parkinson disease
- juvenile dermatomyositis
role in cell
- quantity
- recovery in
- synaptic transmission
- recovery
- plasticity
- maturation
- maintenance in
- synaptic depression
- activity
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- punctate structures
- vesicles
- Mitochondria
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sybu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic activity
- synapse maturation
- axon transport of mitochondrion
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytoplasmic vesicle
- vesicle
- Golgi membrane
- cytoplasmic microtubule
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding