Mis18a Gene Summary [Rat]
Predicted to enable identical protein binding activity and protein-macromolecule adaptor activity. Predicted to be involved in CENP-A containing chromatin assembly and chromosome segregation. Predicted to act upstream of or within pericentric heterochromatin organization and protein localization to chromosome, centromeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of CENP-A recruiting complex. Predicted to be active in chromatin; chromosome, centromeric region; and nucleus. Orthologous to human MIS18A (MIS18 kinetochore protein A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mis18a |
| Official Name | MIS18 kinetochore protein A [Source:RGD Symbol;Acc:1310778] |
| Ensembl ID | ENSRNOG00000021555 |
| Bio databases IDs | |
| Aliases | MIS18 kinetochore protein A |
| Synonyms | 2610039C10Rik, 2810018N07Rik, B28, C21orf45, C21orf46, FASP1, hMis18alpha, LOC105372778, MIS18alpha, MIS18 kinetochore protein A, RGD1310778 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mis18a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RLR_C_like
- protein binding activity, bridging
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mis18a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chromosome segregation
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding