Clasp1 Gene Summary [Rat]
Predicted to enable dystroglycan binding activity; kinetochore binding activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; negative regulation of cytoskeleton organization; and positive regulation of extracellular matrix organization. Predicted to act upstream of or within cell division; establishment of spindle orientation; and negative regulation of microtubule depolymerization. Located in kinetochore. Orthologous to human CLASP1 (cytoplasmic linker associated protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clasp1 |
| Official Name | cytoplasmic linker associated protein 1 [Source:RGD Symbol;Acc:1310970] |
| Ensembl ID | ENSRNOG00000002376 |
| Bio databases IDs | |
| Aliases | cytoplasmic linker associated protein 1 |
| Synonyms | 1700030C23Rik, 5730583A19Rik, B130045P17Rik, CLASP1alpha, CLIP associating protein 1, cytoplasmic linker associated protein 1, MAST1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clasp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- HEAT repeat
- binding protein
- microtubule plus-end binding
- protein binding
- CLASP N terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteodysplastic primordial dwarfism type 1
- spondyloepiphyseal dysplasia congenita
- Roifman syndrome
- Lowry Wood syndrome
- gout
- androgenic alopecia
- RNU4ATAC spectrum disorder
- cough
regulates
role in cell
- apoptosis
- assembly
- formation
- cell division
- migration
- dynamics
- cohesion
- depolymerization
- migration by
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- microtubule cytoskeleton
- focal adhesions
- cell cortex
- centrosome
- Golgi Apparatus
- microtubules
- midbody
- cytosol
- spindle fibers
- cytoplasmic microtubule
- kinetochore microtubule
- plus end of microtubule
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clasp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- microtubule anchoring
- Golgi organization
- mitotic spindle organization
- establishment of spindle orientation
- positive regulation of exocytosis
- cell division
- regulation of epithelial to mesenchymal transition
- positive regulation of epithelial cell migration
- negative regulation of microtubule polymerization or depolymerization
- exit from mitosis
- positive regulation of microtubule polymerization
- regulation of gastrulation
- establishment of mitotic spindle localization
- establishment or maintenance of cell polarity
- microtubule nucleation
- negative regulation of microtubule depolymerization
- microtubule cytoskeleton organization
- positive regulation of extracellular matrix disassembly
- astral microtubule organization
- regulation of focal adhesion assembly
- negative regulation of stress fiber assembly
- microtubule bundle formation
- vesicle targeting
- microtubule organizing center organization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- centrosomal corona
- microtubule plus end
- Golgi apparatus
- cytoplasmic microtubule
- kinetochore
- spindle microtubule
- centrosome
- focal adhesion
- microtubule organizing center
- mitotic spindle
- kinetochore microtubule
- cell cortex
- membrane
- cytosol
- cortical microtubule cytoskeleton
- basal cortex
Molecular Function
What the gene product does at the molecular level
- kinetochore binding
- protein binding
- microtubule plus-end binding
- dystroglycan binding
- microtubule binding