Ddc Gene Summary [Rat]
Enables several functions, including amino acid binding activity; aromatic-L-amino-acid decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; dopamine biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddc |
| Official Name | dopa decarboxylase [Source:RGD Symbol;Acc:2494] |
| Ensembl ID | ENSRNOG00000004327 |
| Bio databases IDs | |
| Aliases | dopa decarboxylase |
| Synonyms | AAAD, AADC, ADC, aromatic L-amino acid decarboxylase, Dihydroxyphenylalanine decarboxylase, DOPA DECARBOXYLASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- pyridoxal phosphate binding
- aromatic-L-amino-acid decarboxylase
- enzyme binding
- AAT_I
- protein domain specific binding
- enzyme
- protein binding
- amino acid binding
Pathways
Biological processes and signaling networks where the Ddc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- deficiency of aromatic-l-amino-acid decarboxylase
- idiopathic Parkinson disease
- Parkinson disease
- acute lymphoblastic leukemia
- postencephalitic Parkinsonism
- congestive heart failure
- anhedonia
- non-insulin-dependent diabetes mellitus
- dyskinesia
role in cell
- replication in
- conversion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- cytosol
- synaptic vesicles
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- serotonin biosynthetic process
- dopamine biosynthetic process
- kidney development
- cellular amino acid metabolic process
- gene expression
- catecholamine metabolic process
- carboxylic acid metabolic process
- response to toxin
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- aromatic-L-amino-acid decarboxylase activity
- enzyme binding