Gast Gene Summary [Rat]
Enables hormone activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be active in extracellular space. Orthologous to human GAST (gastrin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gast |
| Official Name | gastrin [Source:RGD Symbol;Acc:2662] |
| Ensembl ID | ENSRNOG00000014740 |
| Bio databases IDs | |
| Aliases | gastrin |
| Synonyms | GAS, GASTRIN, Gastrin-17, PPG34 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gast often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gastrin/cholecystokinin family
- hormone
- protein binding
- ATPase-binding domain
Pathways
Biological processes and signaling networks where the Gast gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cholecystokinin/Gastrin-mediated Signaling
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Gap Junction Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- JAK/Stat Signaling
- Molecular Mechanisms of Cancer
- Relaxin Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- anemia
- splenomegaly
- gastric cancer
- pancreatic neoplasia
- pancreatic neoplasm
- obesity
- hyperglycemia
- thrombocytosis
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- binding in
- growth
- activation in
- production in
- adhesion
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Plasma Membrane
- nerve ending
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gast gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- G-protein coupled receptor signaling pathway
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity