Cep131 Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including intraciliary transport involved in cilium assembly; protein localization to centrosome; and regulation of centrosome duplication. Predicted to act upstream of or within cilium organization and spermatid development. Predicted to be located in several cellular components, including acrosomal vesicle; microtubule organizing center; and sperm head-tail coupling apparatus. Predicted to be active in centriolar satellite. Orthologous to human CEP131 (centrosomal protein 131). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cep131 |
| Official Name | centrosomal protein 131 [Source:RGD Symbol;Acc:1307745] |
| Ensembl ID | ENSRNOG00000004430 |
| Bio databases IDs | |
| Aliases | centrosomal protein 131 |
| Synonyms | AZ1, Azi, AZI1, centrosomal protein 131, ZA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cep131 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein homodimerization
- protein binding
- Intermediate filament protein
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- frontotemporal dementia
role in cell
- expression in
- proliferation
- development
- formation
- assembly
- duplication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- intracellular membrane-bounded organelle
- centriolar satellite
- cilia
- basal bodies
- centrosome
- centriole
- cytoplasmic bridges
- cytosol
- nucleoplasm
- nuclear envelope
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cep131 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- cilium morphogenesis
- regulation of centrosome duplication
- positive regulation of cell proliferation
- intraflagellar transport involved in cilium morphogenesis
- sperm axoneme assembly
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear membrane
- centriole
- cilium basal body
- acrosomal vesicle
- centriolar satellite
- cytosol
- ciliary transition zone
- manchette
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity