Prpf40a Gene Summary [Rat]
Predicted to enable RNA binding activity and proline-rich region binding activity. Predicted to be involved in several processes, including mRNA splicing, via spliceosome; regulation of cell shape; and regulation of cytokinesis. Predicted to be located in nuclear matrix and nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Orthologous to human PRPF40A (pre-mRNA processing factor 40 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prpf40a |
| Official Name | pre-mRNA processing factor 40 homolog A [Source:RGD Symbol;Acc:1311401] |
| Ensembl ID | ENSRNOG00000004864 |
| Bio databases IDs | |
| Aliases | pre-mRNA processing factor 40 homolog A |
| Synonyms | 2810012K09Rik, FBP-11, FLAF1, Fnbp11, FNBP3, HIP-10, HYPA, NY-REN-6, pre-mRNA processing factor 40A, pre-mRNA processing factor 40 homolog A, Prp40 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prpf40a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FF domain
- Domain with 2 conserved Trp (W) residues
- Contains two conserved F residues
- WW
- protein binding
- WW domain
Pathways
Biological processes and signaling networks where the Prpf40a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prpf40a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cell division
- nuclear mRNA cis splicing, via spliceosome
- cytoskeleton organization
- regulation of cytokinesis
- cell migration
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- membrane
- nuclear matrix
- U2-type prespliceosome
- U1 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding