CEP131 Gene Summary [Human]
Enables protein homodimerization activity. Involved in several processes, including intraciliary transport involved in cilium assembly; protein localization to centrosome; and regulation of centrosome duplication. Located in several cellular components, including ciliary transition zone; intercellular bridge; and microtubule organizing center. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CEP131 |
| Official Name | centrosomal protein 131 [Source:HGNC Symbol;Acc:HGNC:29511] |
| Ensembl ID | ENSG00000141577 |
| Bio databases IDs | |
| Aliases | centrosomal protein 131 |
| Synonyms | AZ1, Azi, AZI1, centrosomal protein 131, ZA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEP131 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein homodimerization
- protein binding
- Intermediate filament protein
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- frontotemporal dementia
role in cell
- expression in
- proliferation
- development
- formation
- assembly
- duplication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- intracellular membrane-bounded organelle
- centriolar satellite
- cilia
- basal bodies
- centrosome
- centriole
- cytoplasmic bridges
- cytosol
- nucleoplasm
- nuclear envelope
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEP131 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- cilium morphogenesis
- regulation of centrosome duplication
- positive regulation of cell proliferation
- intraflagellar transport involved in cilium morphogenesis
- sperm axoneme assembly
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear membrane
- centriole
- cilium basal body
- acrosomal vesicle
- centriolar satellite
- cytosol
- ciliary transition zone
- manchette
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity