Wdr60 Gene Summary [Rat]
Predicted to enable dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to be located in ciliary base; cytosol; and microtubule cytoskeleton. Predicted to be part of cytoplasmic dynein complex. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr60 |
| Official Name | WD repeat domain 60 [Source:RGD Symbol;Acc:1306493] |
| Ensembl ID | ENSRNOG00000004520 |
| Bio databases IDs | |
| Aliases | WD repeat domain 60 |
| Synonyms | CFAP163, D430033N04Rik, DIC6, Dync2l1, dynein 2 intermediate chain 1, FAP163, RGD1306493, SRPS6, SRTD8, WDR60 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wdr60 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pre-mRNA-splicing factor 38-associated hydrophilic C-term
- dynein light chain binding
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Wdr60 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary tip
- cilia
- Nucleus
- basal bodies
- centrosome
- microtubule organizing centers
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wdr60 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar retrograde transport
- embryonic skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- extracellular space
- centrosome
- cytoplasmic dynein complex
- cytoplasm
- interphase microtubule organizing center
- spindle pole
- cilium
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein heavy chain binding
- dynein light chain binding