Ide Gene Summary [Rat]
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and amyloid-beta binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; hormone catabolic process; and negative regulation of proteolysis. Located in cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ide |
| Official Name | insulin degrading enzyme [Source:RGD Symbol;Acc:2861] |
| Ensembl ID | ENSRNOG00000016833 |
| Bio databases IDs | |
| Aliases | insulin degrading enzyme |
| Synonyms | 1300012G03Rik, 4833415K22Rik, INSDEGM, INSULIN-DEGRADING ENZYME, INSULYSIN, LOC105378434 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ide often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- peptidase
- ATP binding
- insulysin
- protein binding
- beta-amyloid binding
- Peptidase M16 inactive domain
- identical protein binding
- ATPase
- polypeptide hormone binding
- endopeptidase
- binding protein
- zinc ion binding
- Middle or third domain of peptidase_M16
- protein homodimerization
- Insulinase (Peptidase family M16)
- peroxisome targeting signal
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Ide gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- infectious conjunctivitis
- microgliosis
- non-insulin-dependent diabetes mellitus
- Alzheimer disease
- bipolar disorder
- burn
- keratitis
- sporadic amyotrophic lateral sclerosis
- glioblastoma
role in cell
- quantity
- expression in
- apoptosis
- proliferation
- survival
- degradation in
- mitochondrial respiration in
- formation
- clearance
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- peroxisomal matrix
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- endosomes
- Mitochondria
- cytosol
- plasma membrane extracellular face
- basolateral membrane
- perinuclear space
- peroxisomes
- exosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ide gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of protein binding
- insulin receptor signaling pathway
- protein catabolic process
- positive regulation of protein catabolic process
- hormone catabolic process
- beta-amyloid clearance
- peptide catabolic process
- bradykinin catabolic process
- proteolysis
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- ubiquitin homeostasis
- beta-amyloid metabolic process
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- external side of plasma membrane
- cytosol
- peroxisomal matrix
- basolateral plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- insulin binding
- ATP binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- endopeptidase activity
- peptide binding
- viral receptor activity
- metalloendopeptidase activity