Pam16 Gene Summary [Rat]
Involved in negative regulation of apoptotic DNA fragmentation and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in matrix side of mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of PAM complex, Tim23 associated import motor. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pam16 |
| Official Name | presequence translocase associated motor 16 [Source:RGD Symbol;Acc:1598163] |
| Ensembl ID | ENSRNOG00000004608 |
| Bio databases IDs | |
| Aliases | presequence translocase associated motor 16 |
| Synonyms | 2010110I09Rik, CGI-136, LOC687579, MAGMAS, presequence translocase associated motor 16, presequence translocase-asssociated motor 16, SMDMDM, TIM16, TIMM16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pam16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ
- protein binding
Pathways
Biological processes and signaling networks where the Pam16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Megarbane-Dagher-Melki type spondylometaphyseal dysplasia
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- male pattern hair loss
regulates
- caspase 3/7
- ATPase
role in cell
- apoptosis
- synthesis in
- ossification by
- G1 phase
- fragmentation in
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pam16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial matrix
- negative regulation of ATPase activity
- ossification
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane presequence translocase complex
- mitochondrial matrix
- presequence translocase-associated import motor
- macromolecular complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding