Tlr5 Gene Summary [Rat]
Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlr5 |
| Official Name | toll-like receptor 5 [Source:RGD Symbol;Acc:631351] |
| Ensembl ID | ENSRNOG00000022067 |
| Bio databases IDs | |
| Aliases | toll-like receptor 5 |
| Synonyms | FLJ10052, MELIOS, SLE1, SLEB1, TIL3, toll-like receptor 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tlr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- YXXM motif
- ectodomain
- SEFIR domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- TIR domain
- leucine-rich repeat
- interleukin-1 receptor binding
- transmembrane domain
- intracellular domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tlr5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Parkinson's Signaling Pathway
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- hypertension
- infection
- breast cancer
- weight gain
- systemic lupus erythematosus
- schizophrenia
- hepatic steatosis
- pancreatitis
- psoriasis
role in cell
- expression in
- phosphorylation in
- proliferation
- quantity
- induction in
- activation in
- cell death
- activation
- shedding in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- cytosol
- apical cell surfaces
- basolateral cell surfaces
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tlr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor signaling pathway
- positive regulation of interleukin-8 production
- cellular response to mechanical stimulus
- inflammatory response
- innate immune response
- toll-like receptor 5 signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity
- interleukin-1 receptor binding